![]() Major bleeding episodes were experienced by up to 13% of people taking Lovenox, and a fraction of those included bleeding in the brain, bleeding in the abdomen, and bleeding around the spinal cord. Internal bleeding is a potentially serious problem because it can’t be seen. Healthcare professionals consider major bleeding as losing enough blood to require medical treatment or reducing the body’s hemoglobin levels by two percent. Minor bleeding and bruising can be a nuisance, but major bleeding episodes or internal bleeding can be life-threatening. Most people taking Lovenox will experience more frequent bleeding and bruising than normal, but these usually are minor episodes. Lovenox blocks the ability of the body to form blood clots, which are the body’s way of stopping bleeding. Low platelet counts (thrombocytopenia) or platelet death (thrombocytosis).Bleeding around the spinal cord (epidural or spinal hematoma).The most serious side effects associated with Lovenox are: The most common side effects of Lovenox are: RELATED: What is Lovenox? Common side effects of Lovenox To minimize risks, people taking Lovenox should be familiar with possible side effects, drug interactions, warnings, and especially the ways to prevent problems when taking this drug. All blood thinners are potentially hazardous drugs and Lovenox is no exception. The active ingredient in Lovenox, enoxaparin sodium, belongs to a family of anticoagulants (“blood thinners”) called low molecular weight heparins (LMWH). It is also used to prevent blood clots in people who are hospitalized, have unstable angina (chest pain), have had a heart attack, or who are undergoing hip replacement surgery, knee replacement surgery, or abdominal surgery. It is used to treat people diagnosed with a blood clot, such as a deep vein thrombosis (DVT) or pulmonary embolism (PE). Lovenox is a brand-name medication that is injected under the skin (subcutaneously) once or twice a day to prevent or treat blood clots. Because fatal reactions, often resembling anaphylaxis, have been reported with protamine sulfate, it should be given only when resuscitation equipment and treatment of anaphylactic shock are readily available.Common Lovenox side effects | Serious side effects | Lovenox and bleeding | How long do side effects last? | Warnings | Interactions | How to avoid side effects Administration of protamine sulfate can cause severe hypotensive and anaphylactoid reactions. Particular care should be taken to avoid overdosage with protamine sulfate. Neutralization of enoxaparin by protamine Time Since LOVENOX DoseĪ second infusion of 0.5 mg protamine per 1 mg LOVENOX may be administered if the aPTT measured 2 to 4 hours after the first infusion remains prolonged. Attending physicians confronted with a potential overdosage of enoxaparin should always use their best clinical judgment in determining the appropriate dosing regimen of protamine to be administered. In the event that prompt reversal of the anticoagulant effects of enoxaparin is required at any time after LOVENOX dosing, the following table is provided as a guide for initial use of protamine. Anti-factor Xa activity is never completely neutralized (maximum about 60%). However, even with higher doses of protamine, the aPTT may remain prolonged to a greater extent than usually seen with unfractionated heparin. This effect may be largely neutralized by slow intravenous injection of protamine sulfate. The anticoagulant effect of LOVENOX is inhibited by protamine. In more serious cases, protamine should be administered. LOVENOX should be immediately discontinued, at least temporarily, in cases of significant excess dosage. Accidental overdosage following administration of LOVENOX (enoxaparin) may lead to hemorrhagic complications.
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